“We have a particular focus on GPCRs for which the endogenous ligand remains unknown. These so-called orphan GPCRs provide significant opportunities for drug development to address a broad ...

STRASBOURG, France; MONTREAL, Canada; BOSTON, MA, USA I March 20, 2025 I Domain Therapeutics ("Domain" or "the Company"), the GPCR experts harnessing deep ...

We also vigorously performed the “deorphanization” of orphan GPCRs during the project, and identified novel ligands for GPR103 and GPR7/8. We showed that the ligand of GPR103 has an essential function ...

Their simulations revealed that so-called “orphan” GPCR—receptors with unidentified ligands—bound strongly to metabolites negatively correlated with AD risk. 7 These findings bring these underexplored ...

However, the role of many of them is poorly understood, and it is thought these so-called 'orphan' GPCRs could provide a rich supply of new medicines. Septerna's lead and currently only clinical ...