为探究阿尔茨海默病（AD）患者抑郁的临床特征及相关机制，首都医科大学附属北京天坛医院研究人员开展研究，发现脑脊液中 orexin A 水平升高可介导脑萎缩与抑郁的关联，对预测 AD 患者抑郁有重要意义。 研究背景 在神经医学领域，阿尔茨海默病（Alzheimer’s ...

A readily available sleep aid has been shown to have a surprising side effect on brain health, seemingly protecting the organ ...

In this randomized controlled trial, oveporexton use significantly improved symptoms of narcolepsy over eight weeks. 2.

Without 8 or 9 hours of sleep, most of us end up staggering around like zombies. But according to a new study, some people ...

Studies in mice by researchers at ETH Zurich now indicate that the brain chemical orexin, and the neurons that produce it, may mediate that decision. The team developed a task that allowed them to ...

Narcolepsy type 1 is a disorder of hypersomnolence caused by a loss of orexin neurons, which results in low orexin levels in the brain. In this phase 2, randomized, placebo-controlled trial ...

Between 2005 and 2011, Burdakov's research lab (then at the University of Cambridge) contributed to the identification and characterization of glucose-sensing in orexin neurons. These are ...

Brendon Yee, PhD, professor and respiratory and sleep physician, Woolcock Institute of Medical Research, discusses the success of ALKS 2680, an investigational oral selective orexin 2 receptor ...

Orexin, also known as hypocretin, is a brain hormone that helps regulate sleep. A deficiency of this hormone can cause a person to develop type 1 narcolepsy. Type 1 narcolepsy, formerly known as ...

Orexin is essential in choosing between exercise and snacking Mice with active orexin systems preferred exercise over sugary treats Insights into orexin could lead to better strategies for ...

They deciphered which brain chemical and which nerve cells mediate this decision: the messenger substance orexin and the neurons that produce it. These neuroscientific fundamentals are relevant ...