Skeptics of the idea that oncogene-induced cell senescence is a potential anticancer mechanism have correctly pointed out the many differences between in vitro and in vivo conditions. 46 For ...

Oncogene-induced senescence is a mechanism of tumor suppression that restricts the progression of benign tumors. Important advances have been made toward elucidating the mechanisms that regulate ...

Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence (OIS) could play a key role in future cancer therapy. Researchers have now ...

Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence (OIS) could play a key role in future cancer therapy. Researchers have now ...

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence. Cell Reports , 2013; DOI: 10.1016/j.celrep.2013.03.004 Cite This Page : ...

Michaloglou et al., "BRAFE600-associated senescence-like cell cycle arrest of human naevi," Nature, 436:720-4, 2005. (Cited in 92 papers) The finding: Two groups of researchers from the Netherlands ...

“What was unexpected was just the fact that cancer cells had retained the ability to undergo senescence at all,” says Dean Felsher, M.D., Ph.D., associate professor of medicine and patholog ...

These mutated cells first expand but soon thereafter enter oncogene-induced senescence (OIS). The end of this process is a circumscribed lesion with relatively higher numbers of senescent melanocytes.