elegans and mammalian neuronal cultures (Fonte et al, 2011). We propose that a primary mechanism of Abeta toxicity is the formation of membrane-damaging oligomers, which is blocked by the G37L ...

"Alzheimer's disease is a brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to ...

Yet as the different pathological roles of distinct Aβ species have become clearer, the possibility of selectively targeting specific types of Aβ, as with ACU193’s targeting of Aβ oligomers ...

Expansion of trinucleotide repeats, such as CAG that encodes for polyglutamine, is associated with a number of neurodegenerative disorders. Expanded polyglutamine fragments form aggregates that have ...

Most pathological aggregates, called oligomers, are difficult to study with traditional methods, due to their fleeting nature and structural variability. Antibodies, known for their precise target ...

Most pathological aggregates, called oligomers, are difficult to study with traditional methods, due to their fleeting nature and structural variability. Antibodies, known for their precise target ...

The live webcasts may be accessed under the Investors tab on www.acumenpharm.com and will be archived for 90 days.

The dosing of several patients marks an important milestone in assessing the safety, tolerability, and pharmacokinetics of PMN310 and underscores ProMIS's commitment to addressing the urgent need for ...

Peptide therapeutics, such as GLP-1a (glucagon-like peptide-1 agonists), offer promising treatments for weight control and ...

Zervimesine is an investigational oral, once-daily pill being developed for the treatment of CNS diseases, including ...

In this study, the researchers revealed that autophagy pathway in astrocytes (non-neuronal cells in the brain) removes amyloid-beta (Aβ) oligomers, the toxic proteins found in the brains of AD ...