为解决实时活细胞 DNA 可视化难题，研究人员开展了利用 Oligo-LiveFISH 动态追踪非重复基因组位点的研究。该技术实现 20nm 空间和 50ms 时间分辨率的染色质成像，揭示染色质通讯模式，对研究 3D 基因组动力学意义重大。 3D 基因组动力学对细胞功能和疾病至关重要。

为解决寡核苷酸药物穿越血脑屏障（BBB）及快速降低毒性蛋白的挑战，研究人员开发脑穿透性 DNA 纳米花结合寡核苷酸靶向蛋白降解嵌合体（Oligo-PROTAC）。以 FUS 为模型，证实其通过泛素 - 蛋白酶体通路降解 FUS，单次静脉注射可穿透 BBB 并持续降靶，为神经退行性 ...

加州弗里蒙特--(BUSINESS WIRE)--(美国商业资讯)--Biolytic Lab Performance Inc.推出其新型寡核苷酸合成仪Dr. Oligo 768XLc ... 大量独特的DNA和RNA对他们的产品 ...

Phosphoramidite chemistry, developed in the 1980s, is the standard method for DNA oligo synthesis. That process has been optimized for speed and throughput over the last few decades thanks to ...

These short DNA or RNA molecules modulate gene expression ... reagents typically used to synthesize oligonucleotides and can be used in standard oligonucleotide-making equipment.

Assistant Professor Tomohide Takaya of Shinshu University recently reported that oligo DNA derived from the genome sequence of lactic acid bacteria promotes differentiation into skeletal muscle by ...

Oligonucleotides are usually made up of 13 to 25 nucleotides and are designed to hybridize specifically to DNA or RNA sequences. Solid-phase clinical synthesis is used to manufacture these small ...

Terminal deoxynucleotidyl transferase (TdT) is the workhorse of enzymatic DNA synthesis technologies [Ansa Biotechnologies] The gold standard for DNA writing, phosphoramidite chemistry, works ...