After synthesis comes the critical step of purification. Achieving balance between high purity and good recovery rates is often a challenge in oligonucleotide purification. Selecting the right ...

Therapeutic synthetic oligonucleotides face unique analytical challenges in late-stage development. Meeting stringent regulatory requirements demands highly specific and sensitive methods like LC-MS.

We find purification of the oligonucleotides by ... at least six Cm R /Km R bacterial clones for each individual target oligonucleotide when cloning individual shRNAs, or ensure at least threefold ...