An orthogonal central dogma may insulate genetic programs from host regulation and allow expansion of the roles of these processes within the cell. We define an orthogonal system as a network of ...

在一项新的研究中，来自美国宾夕法尼亚大学佩雷尔曼医学院和斯坦福大学医学院的研究人员设计出一对人正交IL-2（orthogonal IL-2, ortho-hIL-2）和人 ...

To increase the number of available gates, we used DNA synthesis to access repressors selected from the sequence database and screened them to identify an orthogonal subset. Using an in vitro ...

From RNA interference (RNAi) to CRISPR, there are several methods that researchers can use to manipulate gene function, each with its own strengths and weaknesses. Orthogonal validation – the ...

Obtaining appropriate property data for an application sometimes necessitates the employment of both complimentary and orthogonal analytical methods. These terms illustrate how information from ...

Furthermore, says Mills, with the widespread adoption of CRISPR technologies, orthogonal validation is becoming more prevalent, especially in high impact journals. Another strong application of ...

In mathematical circles, the word ‘orthogonal’ is used to define relations or objects that are non-overlapping, uncorrelated or independent. This definition is highly relevant when referring to ...

There is a resounding consensus among industry experts that multiple bioequivalency approaches and orthogonal methods will be required for the assessment of biosimilarity. Pharmaceutical Technology ...

There is evidence that the orthogonal grid plan, which is one of the most common types of urban planning today, dates back to antiquity. Streets intersect at right angles to each other ...