The Tiam1/Rac1 structure highlights the interactions that catalyse nucleotide exchange on Rho family G proteins, and illustrates structural determinants dictating specificity between individual ...

Despite extensive data on kinesin-1, the structural connection between its nucleotide cycle and movement has remained elusive, mostly because the structure of the critical tubulin-bound apo ...

Williams, W. R. (2025) Nucleotide Relative Molecular Similarity within Anti-Psychotic Drug Structures. Journal of Biosciences and Medicines, 13, 106-117. doi: 10.4236/jbm.2025.136010 .

In CBASS systems, a cGAS/DncV-like nucleotidyltransferase synthesizes cyclic di- or tri-nucleotide second messengers in response to infection, and these molecules activate diverse effectors to mediate ...

Now researchers have used cryo-electron microscopy to solve the first structure of an active form of an RNR. These complicated enzymes consist of two subunits, α and β. In the Escherichia ...