Long-lived animals representing distinct longevity pathways exhibit small nucleoli, and decreased expression of rRNA, ribosomal proteins, and the nucleolar protein fibrillarin, dependent on NCL-1.

2024年8月21日，中国科学院广州生物医药与健康研究院潘光锦课题组在Nature Communications上发表了题为“METTL3/METTL14 maintain human nucleoli integrity by mediating SUV39H1/H2 degradation”的研究论文 2024年8月21日，中国科学院广州生物医药与健康研究院潘光锦课题组在Nature ...

All of the mutants showed smaller nucleoli than their shorter-lived relatives, independent of the pathway that led to their longevity. The nucleolus is a tiny structure within the cell nucleus where ...

This organization gives rise to unique pH profiles within nucleoli, which they measured and compared with the pH of nearby non-nucleolar condensates including nuclear speckles and Cajal bodies.

Eventually the cell dies. This suggests that nucleoli are a powerful new target for the development of new cancer drugs. Dr. Carlos Rubbi, based at the Liverpool Cancer Research UK Centre ...

An automated image classification pipeline detects and analyzes prominent nucleoli in ccRCC images to classify them as either low (Fuhrman grade 1 and 2) or high (Fuhrman grade 3 and 4). The pipeline ...