The results of recent experiments implicate this signalling pathway in many stages of heart development, and provide mechanistic insight into the vital functions of Notch in the aetiology of ...

Specifically, we would like to understand how these glycosyltransferases regulate the activity of the Notch signaling pathway in a dosage-sensitive and tissue-specific manner. We have reported a mouse ...

Colorectal cancer (CRC) is a type of cancer that begins in the colon (large intestine) or rectum, which are parts of the digestive system.

Colorectal cancer (CRC) is a type of cancer that begins in the colon (large intestine) or rectum, which are parts of the ...

As a post-doctoral researcher at Yale University and at the Institute for Molecular Biology and Biotechnology on Crete, Greece, she studied functions of the Notch signaling pathway during nervous ...

The authors examine the role of Numb, a Notch inhibitor, in intestinal stem cell self-renewal in Drosophila during homeostasis and regeneration. This is an important study providing evidence of a Numb ...

A groundbreaking review highlights significant advancements in the understanding and treatment of cerebral vascular ...

We found that tumor-resident cytotoxic type 1 innate lymphoid cells (ILC1s) arise from a differentiation pathway distinct from conventional natural killer (NK ... induces monocyte-derived ...