Characterization of Notch signalling started with the discovery of the Notch gene in Drosophila melanogaster as a sex-linked mutation displaying a serrated wing margin phenotype 1,2,3.

Frc is a UDP–sugar transporter. A mutation affecting limb development in Drosophila was identified in a genetic screen for mutations induced by the P–Gal4 element. The phenotype of this line ...

For instance, Notch signaling specifies the wing margin, a line of cells that organizes the patterning and outgrowth of the wing proper. Loss of Notch signaling here results in loss of wing tissue. We ...

Crucial Roles In Drosophila Development For Little-Known Protein Date: April 7, 2005 Source: Public Library Of Science Summary: The Notch pathway is an important mechanism for communication ...

Please use one of the following formats to cite this article in your essay, paper or report: APA. Roy, Amrita. (2019, February 26). Notch Signaling and Diseases.

By using the Drosophila pupal wing, we are interested in elucidating how tissue morphogenesis and dynamic cellular communications are regulated at the subcellular level. Contact Osamu Shimmi, PhD, ...

Late in their lives, and at about the same time they resist tumor formation, stem cells begin expressing a transcription factor protein, known as Eyeless in Drosophila and Pax6 in humans. Its ...