How does the cell cycle affect our daily lives? Indeed, most cancers are the result of inappropriate cell division, often stemming from aberrations in normal cell cycle regulation. Considerable ...

How is a normal cell transformed into a cancerous cell? The proteins involved in cell division events no longer appropriately drive progression from one cell cycle stage to the next. Cells that ...

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

New research offers unprecedented insight into how an enigmatic enzyme, known as CDK7, drives the cell cycle and cell proliferation.

"This work addresses a long-standing mystery surrounding an enzyme critical for regulating the cell cycle and cell proliferation ... While CDK7 is critical for normal development, certain ...