For over two decades, Lipton has been investigating a chemical process called S-nitrosylation, a post-translational modification whereby an NO-related molecule binds to sulfur atoms in proteins to ...

Central to the dysfunction is the aberrant modification of mitochondrial enzymes by S-nitrosylation, a chemical reaction where nitrogen and oxygen atoms bind to sulfur atoms on proteins.

The intricate modifications of LSD1, including phosphorylation, acetylation, ubiquitination, methylation, SUMOylation, and S-nitrosylation, dictate its enzymatic activity, subcellular localization ...