Sea’s pre-clinical stage neurotherapeutic synthetic oral molecules act at the neurotransmitter glutamate pathway on two clinically validated targets in the CNS (central nervous system) ...

Neurotransmitters are biological molecules that are secreted by neurons and that alter the behaviour of their target neurons or effector cells. The authors uncover slow, facilitating inhibitory ...

An electrical impulse cannot directly cross the gap so a different mechanism has to be used. Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ...

Researchers used advanced cryo-electron microscopy to capture atomic-level images of how glutamate, a key neurotransmitter, ...

However, a series of weak stimuli can combine, increasing the amount of neurotransmitter that is released. This results in enough neurotransmitter being diffused across the synaptic cleft to ...

Scientists have long known that a major molecule responsible for neuron-to-neuron communications is the neurotransmitter ...

SV2A is an emerging target in neurological diseases, a poorly understood transmembrane glycoprotein that is thought to play a role in regulating the release of neurotransmitter molecules from neurons.