Depression, characterized by persistent sadness, hopelessness and a lack of interest in previously enjoyed activities, is one ...

Such steroids are synthesized both in the periphery and in the CNS (neurosteroids), and, therefore, can act as both endocrine and paracrine messengers to facilitate inhibitory neurotransmission.

Neurosteroids regulate both regeneration and repair systems in the brain, and among this class of molecules, allopregnanolone has been broadly investigated for its role to promote regeneration in ...

Neurosteroids demonstrate significant therapeutic promise through the modulation of the GABA system and warrant further ...

As part of their quest for new mechanisms of action for anti-depressives and anxiolytics, Florian Holsboer and Rainer Rupprecht at the Max Planck Institute of Psychiatry in Munich have been ...

The study was not designed to test intellectual function, another component of the disease. ## Loss of Neurosteroids in Neurodegeneration “The finding suggests that the progressive loss of ...

How these neurosteroids are linked to depression and why they work is still to be determined. The new study finds that chronic stress reduces a mouse’s ability to produce and respond to these ...

Brexanolone is a type of neurosteroid that has been studied for the treatment of postpartum depression (PPD) treatment and major depressive disorders (MDD). To date, brexanolone is the first PPD ...

Pessah, Madigan and other researchers in veterinary and human medicine recently formed a joint research group and secured funding to investigate whether abnormal levels of neurosteroids — a group of ...

The researchers were investigating the role of neurosteroids in addiction. These are a class of hormones produced in the brain, and they have been implicated in regulating mood and cognitive ...