One of the key players in migraine is CGRP, a neuropeptide that has been implicated in the pain associated with migraines. Research has shown that CGRP released from sensory neurons can activate ...

Advances in understanding the molecular mechanism of migraine, especially the role of an important trigeminal sensory neuropeptide, CGRP, have promoted alternative approaches to migraine therapy.

Migraines are more than just bad headaches ... shows how stress causes an increase in levels of a potent neuropeptide called pituitary adenylate cyclase-activating polypeptide-38 (PACAP38).