Research from the Voigt lab at the Babraham Institute has investigated the mechanism by which bivalency functions to poise ...

The identity of a neuron is determined by the so-called terminal differentiation genes (TDGs), which are activated by specific transcription factors. It is largely unknown how the TDGs are ...

Understanding how cells transform into specialized types during human development is a central challenge in biology. This ...

Cut off any part of this worm's body and it will regrow. This is the spectacular yet mysterious regenerative ability of ...

In addition to cell fate, we are interested in defining the molecular pathways that control timing of human differentiation including cell fate specification, neuronal maturation and the programming ...

This important study provides new evidence on the role of norepinephrine (NE) release in the hippocampus in response to environmental transitions (event boundaries), providing a potential link between ...

There has been considerable progress in understanding the specification of neuronal cell fates and in directing the differentiation of hESCs toward a large diversity of neuronal subtypes. However, the ...

Push-and-pull regulates neuron migration Solecki used super-resolution microscopy to reveal how this two-switch circuit worked. The researchers first noted that differentiated neurons appeared to ...

A research team at KAIST has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation ...

Alcohol exposure significantly reduces viability and induces oxidative stress in both differentiated and undifferentiated neuronal cells in a dose- and exposure duration-dependent manner.