A new study led by Western researchers is the first to identify a factor that could influence how fast the pocket where human immunodeficiency virus (HIV) hides dormant inside of cells shrinks when ...

But how do the virally infected cells protect themselves long enough to manufacture more HIV virions? A recent paper in Nature suggests that Nef may be part of the answer. There has been some ...

Enhancement of HIV-1 Infectivity ... that blocks the function of Env in the virion. Nef enhances infectivity by downregulating this unknown protein in the producer cell and blocking its ...

but it has also been suggested that low levels of intercellular signaling molecules are sufficient for HIV-1 to infect resting human T cells. Nef proteins are important for viral replication and ...

a new study published in Cell Reports on November 22 finds that a protein produced by HIV called Nef can cause long-lasting chronic inflammation in a mouse model of HIV—and that the inflammation may ...

Of note, the vector particles, used in our experiments, were produced in the absence of all HIV-1 accessory proteins (vif, vpr, vpu, and nef), indicating that these proteins do not appear to be ...