Nef protein, which is expressed by HIV during infection, shields the virus from immune detection. This protein reduces a molecule on the surface of the cell that acts as a marker to help the ...

a new study published in Cell Reports on November 22 finds that a protein produced by HIV called Nef can cause long-lasting chronic inflammation in a mouse model of HIV—and that the inflammation may ...

HIV-1 readily invades actively replicating T cells, but it has also been suggested that low levels of intercellular signaling molecules are sufficient for HIV-1 to infect resting human T cells. Nef ...

But how do the virally infected cells protect themselves long enough to manufacture more HIV virions? A recent paper in Nature suggests that Nef may be part of the answer. There has been some ...

The HIV-1 Nef accessory factor promotes viral replication and immune ... However, Nef lacks enzymatic activity and an active site, working instead through protein-protein interactions with diverse ...