Among many of the viral offensive strategies, HIV-1 viral auxiliary proteins (Tat, Rev, Nef, Vif, Vpr and Vpu) play important roles in the host-pathogen interaction and thus have significant ...

The HIV-1 Nef protein plays a crucial role in the virus's ability to replicate and evade the host's immune system. It is known for its ability to downregulate major histocompatibility complex ...

The clear winner was a protein called Nef, which is used by the HIV virus to evade detection by the immune system. It worked ...

Enhancement of HIV-1 Infectivity ... that blocks the function of Env in the virion. Nef enhances infectivity by downregulating this unknown protein in the producer cell and blocking its ...

A new advance may make it possible to use off-the-shelf CAR T cells provided by healthy donors. The new approach studied in mice equipped CAR T cells with the viral protein Nef.

tuberculosis EsxH-EsxG complex also disturbs the process of antigenic presentation via the MHC-II molecule. 6) To stay hidden inside lymphocytes, HIV-1 expresses viral factors such as the negative ...