本文聚焦坏死性凋亡（Necroptosis）、自噬（Autophagy）和 Parthanatos 这三种程序性细胞死亡机制，它们与脑部健康和疾病密切相关。文章总结了其在脑部疾病发病机制中的研究数据，探讨了相关实验模型及治疗方法，有助于推动中枢神经系统疾病防治研究。 坏死性 ...

程序性细胞坏死（necroptosis，以下简称细胞坏死）是一种依赖于RIPK1和RIPK3激酶活性的细胞死亡方式。死亡信号诱导RIPK3激酶的激活，进而磷酸化细胞坏死的特异性执行蛋白MLKL。磷酸化的MLKL（p-MLKL）发生寡聚化并转位到细胞的膜结构上导致细胞膜和细胞器膜的破坏 ...

Walter and Eliza Hall Institute researchers have used lattice light sheet microscopy to visualise cells dying by necroptosis, a form of inflammatory cell death. In this image, purple marks cells ...

Box 1: Apoptosis and necroptosis are distinct types of regulated cell death The electron microscopic images of apoptotic and necroptotic cells depict the morphological characteristics of apoptosis ...

Caption Necroptosis is a form of programmed necrosis that promotes cell death and neuroinflammation, and it is suggested that necroptosis is activated in Alzheimer disease (AD) brains, resulting ...

Tumor cell deaths can benefit tumors. A paradox? Not at all. If, for example, a dying tumor cell undergoes necroptosis, it can release inflammatory factors that can enhance or diminish antitumor ...

Oxidative stress can trigger a type of programmed cell death called necroptosis. According to a new study, the environmental pollutant arsenite can induce necroptosis, but the process requires the ...

Polymyositis (PM) is a chronic inflammatory myopathy wherein muscle weakness is the most common symptom, leading to progressive and persistent disability. Its pathophysiology is assumingly the ...

Necroptosis is a form of programmed cell death, distinguished by rupturing of the cell membrane, swelling of the organelles, and spillage of internal cellular components. This form of cell death ...

Nerve cells die in the context of Alzheimer's disease as a consequence of a well-defined sequence of biochemical reactions, called 'necroptosis.'" Dr. Sriram Balusu, Postdoctoral Researcher ...