本文聚焦坏死性凋亡（Necroptosis）、自噬（Autophagy）和 Parthanatos 这三种程序性细胞死亡机制，它们与脑部健康和疾病密切相关。文章总结了其在脑部疾病发病机制中的研究数据，探讨了相关实验模型及治疗方法，有助于推动中枢神经系统疾病防治研究。

研究首先发现在肌纤维细胞中阻断细胞坏死的发生会破坏肌肉的修复能力，进一步发现坏死的肌纤维能够释放促肌肉干细胞增殖的因子。 程序性细胞坏死（necroptosis，以下简称细胞坏死）是一种依赖于RIPK1和RIPK3激酶活性的细胞 ...

Necroptosis . Nerve cells die in the context of Alzheimer's disease as a consequence of a well-defined sequence of biochemical reactions, called 'necroptosis.'" Dr. Sriram Balusu, ...

Cancer cell death via necroptosis can be accompanied by the release of IL-1a, which can restrict anticancer immunity and promote tumor growth. genprowebdirectory Sign in. Welcome! Log into your ...

Novel sibiriline derivative KWCN-41 shows anti-necroptosis effect. March 28, 2023. Necroptosis is a well-controlled process of programmed necrosis present in inflammatory disorders mainly regulated by ...

Targeting necroptosis for inflammatory myopathies. Tokyo Medical and Dental University. Journal Nature Communications Funder Ministry of Education, Culture, Sports, Science and Technology, JAPAN ...

A new study has suggested that treatment to target necroptosis in muscle fibers using a necroptosis inhibitor lessens myositis-induced muscle weakness as well as muscle cell death and inflammation ...

Necroptosis is associated with a range of pathological conditions. Excitotoxicity, oxidative stress and mitochondrial dysfunction can contribute to necroptosis, and are implicated in conditions ...

Although stress granules are necessary for arsenite-induced necroptosis, their formation isn’t enough to trigger the process. Two other proteins—Z-DNA-binding protein 1 (ZBP1) and receptor ...

image: Sodium Butyrate Inhibits Necroptosis by Regulating MLKL via E2F1 in Intestinal Epithelial Cells of Liver Cirrhosis. view more . Credit: Chong Zhang, Xiaoguang Dou, Yimeng Zhou, Yang Ding ...