Response to immunosuppressive therapy (IST) in younger patients with myelodysplastic syndrome (MDS) has been linked to a T-cell-dominant autoimmune process that impairs hematopoiesis. Analysis of ...

They evolve from naive CD4+ T-cells, which are precursors to memory cells, and can recognize and target germs the body has encountered before. However, the second time the body encounters the germ ...

Ma J, et al. Single-cell analysis pinpoints distinct populations of cytotoxic CD4 + T cells and an IL-10 + CD109 + T H 2 cell population in nasal polyps. Sci Immunol. 2021;6(62): eabg6356. Alkon N, et ...

Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases. Cell Genomics , 2024; 100473 DOI: 10.1016/j.xgen.2023.100473 Cite This Page : ...

Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4 T cell homeostasis. Nature Immunology , 2018; DOI: 10.1038/s41590-018-0103-5 Cite This Page : ...

The proportion of circulating programmed cell death protein-1 (PD-1+) CCR7- T FH lymphocytes (cT FH) was greater among critical COVID-19 patients.Cytotoxic CD4+ T lymphocytes comprised 3.70% of ...

CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) ... Cytokine and inflammatory markers, chimeric antigen receptor (CAR) expansion, ... Orentas RJ, et al: CD22-targeted CAR T cells ...

Another key observation was that the cell sizes of S-specific CD4+ T cells after the first vaccine dose in the elderly were significantly reduced than in adults. Yet again, it pointed to an inept ...

Background: There is substantial evidence that the immune system is dysfunctional in multiple myeloma (MM). Adaptive immune cells, such as CD4 + and CD8 + T cells, are ineffective at controlling MM ...

Malignant T-cell transformation ... CD4, and granzyme B but which did not express TRBC1 chain (a marker for expression of a T-cell ... The pathological diagnosis was reclassified as an indolent ...