recently presented preclinical findings on NTX-101, a murine chimeric antibody designed to specifically bind to nitrated tyrosine on α-synuclein (α-Syn). It was demonstrated that NTX-101 bound both ...

One immunotherapy strategy, rather than directly targeting intracellular α-synuclein, blocks its spread by binding a cellular receptor. Another antibody binds only the nitrated form of α-synuclein, ...

Heneka and colleagues saw nitrated Aβ at the core of amyloid plaques in both human and mouse Alzheimer’s brains. In addition, nitrated Aβ was able to seed plaques in AD model mice, whereas the ...

Scientific American is part of Springer Nature, which owns or has commercial relations with thousands of scientific publications (many of them can be found at www ...