为解析 nafld 相关 gwas 信号中大量非编码区 snps 的功能，研究人员利用 abc 模型整合 15 种肝组织 / 细胞表观基因组数据，构建肝脏增强子 - 基因调控图谱，鉴定 6 个候选基因（含新基因 epha2）及关键 snp（rs2017869），为 nafld 机制研究和药物开发提供新资源。

Nonalcoholic fatty liver disease (NAFLD) is being diagnosed with increasing frequency, and can progress to end-stage liver disease. NAFLD is seen in obese patients in the absence of significant ...

Many controversies regarding the association of liver miRNAs with obesity and nonalcoholic fatty liver diseases (NAFLD) call for additional validations. This study sought to investigate variations ...

编者按：随着肥胖、2型糖尿病和代谢综合征的流行，非酒精性脂肪性肝病（NAFLD）已成为包括我国在内的全球第一大慢性肝脏疾病，并且是普通成人 ...

为解决非酒精性脂肪肝（NAFLD）治疗机制问题，研究人员开展了类胡萝卜素玉米黄质（Torularhodin）对 NAFLD 影响的研究。结果发现其可调节肠道菌群，促进腺苷钴胺合成，减轻 NAFLD。这为 NAFLD 治疗提供了新策略。

编者按：非酒精性脂肪肝（NAFLD）最近更名为代谢功能障碍相关脂肪变性肝病（MASLD），它影响着全球约30%的成年人口，也是肝硬化和肝细胞癌（HCC ...

Fatty liver disease is the most common liver disease in the ... Oakley, F, Anstee, QM, Day, CP. Nonalcoholic fatty liver disease: pathogenesis and disease spectrum. Annu Rev Pathol 2016;11:451-496.

论文第一作者、辛辛那提儿童医院医疗中心的Masaki Kimura说，“葡萄糖激酶调节蛋白（GCKR）-rs1260326突变与NAFLD的关系存在广泛争议。

Researchers found that patients with “lean” nonalcoholic fatty liver disease had altered gut microbiota profiles along with higher bile acid and fibroblast growth factor 19, or FGF19 ...

Even with high and rising prevalence, researchers have struggled to come up with models that accurately mirror NAFLD pathogenesis. Existing rodent models have biological and metabolic ...

2023 FEB 24-- By a News Reporter-Staff News Editor at Insurance Daily News-- Staff editors report on the newly launched clinical trial, NCT05724134, which has the following summary description ...

The pathogenesis of NAFLD is closely linked to the innate immune system. Hepatic lipid accumulation leads to oxidative stress, endoplasmic reticulum (ER) stress, and autophagy dysregulation in ...