The myosin cross-bridge binds to ATP, and then releases its attached actin filament. The cross-bridge then hydrolyses the ATP, and primes itself in preparation for a productive working stroke.

Muscle contraction involves the cyclic interaction of the myosin cross-bridges with the actin filament, which is coupled to steps in the hydrolysis of ATP1. While bound to actin each cross-bridge ...

Myosin makes the moves to keep cell processes humming along by Leah Shaffer, Washington University School of Medicine in St. Louis edited by Stephanie Baum , reviewed by Robert Egan ...

Myosin-5 working stroke and walking on F-actin. (Credit: Klebl et al., 2024) The past years has seen many refinements in cryo-EM, with previously quite manual approaches shifting to microfluidics ...

Excess myosin actin cross-bridge formation and dysregulation of the super-relaxed state are mechanistic hallmarks of HCM. CAMZYOS shifts the overall myosin population towards an energy-sparing ...