Previous attempts to selectively modulate muscarinic receptors by targeting the acetylcholine ... might represent a novel class of antipsychotic drugs.

The drug – a selective muscarinic M4 receptor ... an already-approved muscarinic antagonist designed to reduce M1/M4-related side effects in the peripheral nervous system. Meanwhile, Sosei ...

As per the Brain and Behavior Research Foundation, it combines two compounds called xanomeline and trospium chloride. This is ...

Karuna’s drug is thought to exert its antipsychotic effects through muscarinic M1 and M4 receptors in the central nervous system, targeted by xanomeline, while trospium prevents side effects by ...

Umeclidinium is a long-acting muscarinic antagonist, which is often referred ... The pharmacologic effects of beta2-adrenergic agonist drugs, including vilanterol, are at least in part ...

Cholinergic drugs (acetylcholine and methacholine ... both events explain the increase in airway resistance. Muscarinic (M) receptors involved in the airway tone regulation are as follows ...

(JAMA Network Open) As an FDA decision nears on the muscarinic agonist xanomeline-trospium for schizophrenia -- which could ...

We have long believed in the potential of selective agonists of the muscarinic system to transform the treatment of neurological and neuropsychiatric conditions and look forward reporting further ...

The update presented by Neurocrine included the following information: An End of Phase 2 meeting for NBI-1117568 (NBI-’568, an oral, muscarinic M4 selective agonist) has been completed with the US ...

We have long believed in the potential of selective agonists of the muscarinic system to transform the treatment of neurological and ... and leverages the power of our unique and industry leading GPCR ...