Moreover, they have also been associated with poor tolerability and side effects such as weight gain. Previous attempts to selectively modulate muscarinic receptors by targeting the acetylcholine ...

Adverse effects such as dry mouth ... The widespread expression of all muscarinic receptors, including the M3 subtype, has led to the suggestion that compounds with tissue rather than receptor ...

a novel muscarinic M1/M4 agonist, with trospium, an already-approved muscarinic antagonist designed to reduce M1/M4-related side effects in the peripheral nervous system. Meanwhile, Sosei Heptares ...

Karuna’s drug is thought to exert its antipsychotic effects through muscarinic M1 and M4 receptors in the central nervous system, targeted by xanomeline, while trospium prevents side effects by ...

Anticholinergics prevent the increases in intracellular concentration of Ca++ which is caused by interaction of acetylcholine with the muscarinic ... effects of beta2-adrenoceptor agonist drugs ...