The multivesicular-body (MVB) sorting pathway delivers transmembrane proteins and lipids into small vesicles that invaginate into the lumen of the endosome. MVBs fuse with the vacuole/lysosome and ...

Here we report that transmembrane BAX inhibitor motif-containing 1 (TMBIM1) is an effective suppressor of steatohepatitis and a previously unknown regulator of the multivesicular body (MVB ...

They are generally understood as having been released from cells upon fusion with an intermediate endocytic compartment, or a multivesicular body (MVB). When the MVB fuses with the plasma membrane ...

Multivesicular bodies* are unique organelles in the endocytic pathway that function as intermediates between early and late endosomes. 3 The main function of multivesicular bodies is to separate ...