Soon after rapamycin, the first mTOR inhibitor, emerged in 1990s as a potential treatment against unwanted cell proliferation, many cancer experts had hoped emerging drugs targeting mTOR would ...

Therefore, it is necessary to identify druggable pathways and develop new therapeutic strategies against them. The PI3K-Akt-mTOR pathway regulates several biological functions and it is frequently ...

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer The PI3K/Akt/mTOR pathway is activated in the majority of pancreatic cancers, and inhibition of ...

What is the most troublesome side effect of mTOR inhibitors? In my opinion, pneumonitis is the most troublesome side effect as it can be medically very dangerous if not identified and treated early.