The molecular clock hypothesis was originally proposed by researchers Emile Zuckerkandl and Linus Pauling on the basis of empirical observations, but it soon received theoretical backing when ...

The Beginning of the Molecular Evolutionary Clock. In the early 1960s, biologists began to investigate how proteins in different species evolve at the sequence level (Zuckerkandl 1962, Margoliash ...

The molecular clock has provided a narrative for evolution across short and long timescales. In 2012, researchers concluded that the AIDS epidemic in India had a common ancestor 40 years ago, ...

Molecular clocks are becoming more sophisticated, thanks to improved DNA sequencing, analytical tools and a better understanding of the biological processes behind genetic changes.

SOKENDAI and Kyushu University have uncovered the molecular mechanism that drives the "ticking" of the circadian clock in ...

Molecular Clocks Scattered throughout Your Body (Not Just in the Brain) Keep Your Tissues Humming Genes in the liver, pancreas and other tissues (not just the brain) keep the various parts of the ...

Figure 2. The transcriptional-translational feedback loop of the circadian clock. Circadian locomotor output cycles kaput (CLOCK) and aryl hydrocarbon receptor nuclear translocator-like (BMAL1 ...

Molecular interactions drive the biological clocks in our cells, synchronizing our bodies with the 24-hour cycle of night and day. Certain mutations can shorten clock timing, making some people ...

Molecular clocks in our cells synchronize our bodies with the cycle of night and day, cue us for sleep and waking, and drive daily cycles in virtually every aspect of our physiology. Scientists ...