Both ends can be simply rejoined with little or no further processing (nonhomologous end joining, or NHEJ) or can be repaired using homologous sequences (red DNA; homologous recombination ...
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New strategy suppresses unwanted deletion events to make genome editing safer and more preciseModulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks, BMC Biology (2024).
How do we find out which protein works in a particular DNA repair pathway? We know that if a DNA repair gene is mutated, cells become more sensitive to DNA damaging agents. Researchers in the ...
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