Apoptosis and autophagy constitute the two self-destructive ... response that leads to the removal of damaged organelles (mitophagy and reticulophagy, respectively) and protects cells.

Selective processes related to autophagy, such as mitophagy, were studied to evaluate the impact of damaged mitochondrial clearance on aging neurons. The roles of key proteins such as the ...

Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...

Mitophagy is a selective form of autophagy via which the damaged mitochondria are cleared via the autophagy-lysosome pathway. Mitophagy is an essential part of mitochondrial quality control and ...

Central to the discussion is the concept of mitochondrial quality control, including mitochondrial dynamics (fusion/fission balance) and mitophagy. The review presents evidence linking aberrations in ...