Mitochondrial outer membrane permeabilization is often required for activation of the caspase proteases that cause apoptotic cell death. As a consequence, the integrity of the mitochondrial outer ...

Damaged mitochondria can be removed by mitophagy, but how this organelle is recognized by the autophagy machinery is unclear. Chen and colleagues show that FUNDC1, an integral mitochondrial outer ...

Rather than being like battery chargers, mitochondria are more like the motherboard of the cell.

The soluble Bax protein is responsible for the clearance of old or diseased cells, and when activated, it perforates the cell mitochondrial outer membrane to form pores that trigger programmed ...

Mitochondria are often called the powerhouses of the cell. ... Outer membrane: Small molecules can pass freely through this. This outer portion includes proteins called porins, ...

Removing mitofusins from the outer mitochondrial membrane inhibits fusion and prevents abnormal mitochondria from reintegrating into the network, thereby facilitating mitophagy. 47 This so-called ...

image: MTCH2 acts as a doorway for proteins into the outer mitochondrial membrane. view more Credit: Maria Guna. Mitochondria — the organelles responsible for energy production in human cells ...

Formation of pores in mitochondrial membrane elucidated. University of Freiburg. Journal Nature Structural & Molecular Biology DOI 10.1038/s41594-022-00897-2 ...

Panel D shows mitochondrial ultrastructure and compartmentalization, highlighting the mitochondrial outer membrane (MOM), mitochondrial inner membrane (MIM), and intermembrane space (IMS).