Permeabilization of the mitochondria usually leads ... to serving as a reliable loading control for western blots and other such mundane tasks, GAPDH has suddenly started to blossom on its own.
Inhibition of GAPDH activity by hyperglycemia does not occur when mitochondrial overproduction of superoxide is prevented by either UCP-1 or MnSOD. [36] What happens when GAPDH activity is inhibited?