Researchers have developed engineered human microglia that detect disease-related brain changes and release therapeutic ...

For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation ...

Microglia can be engineered to detect disease-specific brain changes – like amyloid plaques in Alzheimer’s disease – and ...

A new way to deliver disease-fighting proteins throughout the brain may improve the treatment of Alzheimer's disease ...

Microglia degrade plaques, but they are also known to contribute to the formation of plaques. This paradox was intriguing, and the researchers wondered if digestive exophagy could play a role in ...

They constantly scan the brain for signs of trouble – like pathogens ... digesting harmful substances in a process called phagocytosis. Microglia also help regulate inflammation and support ...

Microglia express tight junction molecule (CLDN5) to maintain BBB integrity in early phase and molecule for phagocytosis (CD68) to impair the BBB function in late phase of systemic inflammation.

Image Credit: Axol Bioscience Ltd To evaluate the functional performance of the axoCells Microglia, Axol conducted various assays, such as phagocytosis, chemotaxis, and cytokine release ...