However, the accepted explanation does not explain a unique hallmark of the disease: during the initial stages of IgAN, IgA deposition is seen in the mesangium, an area composed of mesangial cells ...

Panel A (periodic acid–Schiff stain) shows mesangial hypercellularity, with four or more cells per mesangial area (arrow). Panel B (periodic acid–Schiff stain) shows segmental endocapillary ...

Nephropathy is a major complication of diabetes. Alterations of mesangial cells have traditionally been the focus of research in deciphering molecular mechanisms of diabetic nephropathy.

Dr. Robert B. Colvin: Pathological examination of the kidney-biopsy specimen (Figure 1) revealed glomeruli with thickened capillary walls and mild mesangial hypercellularity. A Jones’ silver ...