为探究巨核细胞系细胞与骨骼系统的关系，研究人员敲除小鼠巨核细胞系 Becn1 基因，发现其不影响血小板止血，却调控雄性小鼠骨量。 在人体这个复杂的 “小宇宙” 里，血小板和骨骼看似 “井水不犯河水”，一个忙着止血，守护血管的 “和平”；一个支撑 ...

We show here that cotreatment of K562 cells with PMA and low doses of SB202190 (SB), an inhibitor of the p38 MAPK pathway, induced a majority of cells to differentiate towards the megakaryocytic ...

These pools, in turn, give rise to lineage-restricted neutrophil or macrophage, erythroid, megakaryocytic, B-cell, and T-cell progenitors. Lineage-restricted myeloid repopulating (MyRP ...

It has been shown to inhibit megakaryocytic proliferation in vitro in cells obtained from patients with essential thrombocythemia. In this phase 2 study, we investigated whether imetelstat could ...

Analysis of outcomes in patients (pts) with relapsed/refractory acute promyelocytic leukemia (APL) treated with and without high-dose chemotherapy and hematopoietic stem cell transplantation (HCT).