Known as macrocyclic peptides, these drugs are purported to create the Goldilocks effect—they have the size and shape to provide the advantages of both small- and large-molecule drugs without ...

As of the cut-off date of April 2, 2025, a total of 21 patients had been enrolled and received at least one dose of PAS-004 in six cohorts (Capsules: 2mg, 4mg, 8mg, 15mg, 22mg / Tablets: 4mg). The ...

2023年2月2日，该研究工作以Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P？Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance为题发表于Journal of Medicinal ...

Bayer seeks Japanese marketing authorization for low-dose contrast agent, gadoquatrane for contrast-enhanced MRI of all body regions and CNS: Berlin Tuesday, June 3, 2025, 13:00 H ...

Xiaoling Song and Ph.D. student, Yifan Wu (Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University), on the application of macrocyclic molecules in cancer treatment has ...

Vancomycin 265/309 (85.8%) 76/265 (25.3%) 198/309 (64.1%) † Clinical cure is resolution of diarrhea following the recommended dose of drug (fidaxomicin: 200 mg twice a day; vancomycin: 125 mg ...

At this week’s American Chemical Society Spring meeting, Galderma SA reported the discovery of novel, oral and selective macrocyclic inhibitors of protein kinase C θ (PKCθ) for the potential treatment ...

Roche scientists identified the molecule, a macrocyclic peptide dubbed zosurabalpin, after a screen of 45,000 macrocyclic peptides found a few that killed A. baumannii and other double-membraned ...

Months after hailing macrocyclic peptides as the “next wave of drug discovery,” Merck & Co. has pushed further into the space by penning a $220 million biobucks deal with Unnatural Products.

Xiaoling Song and a Ph.D. student, Yifan Wu (Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University) to summarize the application of macrocyclic molecules in cancer treatment.

Novel manganese-based macrocyclic Magnetic Resonance Imaging (MRI) agent could offer an alternative to gadolinium-based agents Manganese is a trace element naturally occurring in, and efficiently ...