本研究首次明确了： TGR5在帕金森病发病机制中的重要作用；GPS是一种有效的TGR5激动剂，可通过激活Nrf2抗氧化途径，显著改善神经元损伤和氧化应激；为开发基于TGR5的新一代抗氧化治疗药物提供了重要依据。

1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）具有特异性黑质多巴胺神经元的神经毒性作用，能导致人类及多种模型动物出现帕金森病（PD）样症状。

为探究溃疡性结肠炎（UC）中肠上皮细胞凋亡及屏障破坏机制，研究人员开展了 HSP75 对线粒体通透性转换孔（mPTP）调节作用的研究。结果发现 HSP75 在 UC 患者肠黏膜中显著降低，可调节 mPTP 开启，影响细胞凋亡和肠上皮屏障。这为 UC 治疗提供新方向。 在人体的 ...

To investigate the neuroprotective effects of LLDT-67, a novel derivative of triptolide, in MPTP-induced mouse Parkinson's disease (PD) models and in primary cultured astrocytes, and to elucidate ...

线粒体功能障碍的关键上游信号通路主要为Ca2+稳态失调和mPTP过表达且持续开放。 亲环素D（CypD）是mPTP的关键调控蛋白，在AD病理条件下，线粒体内 ...

Then, in 1983, J. William Langston, now director of the California Foundation for Parkinson’s Disease and Related Disorders, in San Jose, identified MPTP as the agent responsible for producing several ...

They were in their 20s, otherwise healthy — until a synthetic drug they had manufactured in makeshift labs left them frozen inside their own bodies. Doctors quickly discovered the cause: MPTP, a ...

In collaboration with Prof. Raimo Tuominen’s and Prof. Barry Hoffer’s groups we have shown that striatal delivery of CDNF protects midbrain DA neurons and restores their function in a rat ...