为探究溃疡性结肠炎（UC）中肠上皮细胞凋亡及屏障破坏机制，研究人员开展了 HSP75 对线粒体通透性转换孔（mPTP）调节作用的研究。结果发现 HSP75 在 UC 患者肠黏膜中显著降低，可调节 mPTP 开启，影响细胞凋亡和肠上皮屏障。这为 UC 治疗提供新方向。 在人体的 ...

1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）具有特异性黑质多巴胺神经元的神经毒性作用，能导致人类及多种模型动物出现帕金森病（PD）样症状。

本研究针对帕金森病(PD)中线粒体功能障碍与内质网应激(ERS)的调控机制不明问题，通过抑制ERS关键靶点Miro1，揭示了4-PBA通过 ...

If you have an existing Uber account: Link your MPTP card by filling out the MPTP form on the Uber website. Once verified, ...

线粒体功能障碍的关键上游信号通路主要为Ca2+稳态失调和mPTP过表达且持续开放。 亲环素D（CypD）是mPTP的关键调控蛋白，在AD病理条件下，线粒体内 ...

To investigate the neuroprotective effects of LLDT-67, a novel derivative of triptolide, in MPTP-induced mouse Parkinson's disease (PD) models and in primary cultured astrocytes, and to elucidate ...

Then, in 1983, J. William Langston, now director of the California Foundation for Parkinson’s Disease and Related Disorders, in San Jose, identified MPTP as the agent responsible for producing several ...

Neuroinflammation contributes to the loss of dopamine neurons and motor dysfunctions in Parkinson's disease (PD). How cell metabolism regulates neuroinflammation by modulating epigenetic modifications ...

They were in their 20s, otherwise healthy — until a synthetic drug they had manufactured in makeshift labs left them frozen inside their own bodies. Doctors quickly discovered the cause: MPTP, a ...