A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.

This approach displays the specificity and sensitivity of conventional MHC multimer staining, yet does not affect the functional status of the cells. Figure 1: Interference of MHC multimer ...

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...