An early study with chimeric receptors between the alpha2c-adrenergic receptor and m3-muscarinic receptor suggested the possible heterodimerization between GPCR types. Direct evidence for GPCR ...

The widespread expression of all muscarinic receptors, including the M3 subtype, has led to the suggestion that compounds with tissue rather than receptor specificity might result in fewer adverse ...

Anticholinergics are competitive inhibitors of acetylcholine at muscarinic receptors (mainly the M3 receptor subtype), and they thereby inhibit involuntary bladder contractions. [19] The effective ...

Anticholinergic medications work by blocking the neurotransmitter acetylcholine from binding to its receptors. For bladder ...

Muscarinic receptors are involved with neurotransmission ... Leaving out activity against M2 and M3 receptors could also improve the safety and tolerability of the drug, by avoiding unwanted ...

It has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of M3 receptors at the smooth muscle leading to ...