Although LROs have many features in common with lysosomes (including low internal pH, distinctive membrane proteins such as the lysosome-associated membrane proteins and similar maturation ...

Alzheimer's disease is one of the world’s most prevalent brain disorders, being extremely difficult to treat. Alzheimer's ...

The lysosomal enzyme beta-glucocerebrosidase is a key player and promising therapeutic target in Parkinson’s disease. Here, Dobert et al. leveraged cryo-EM to solve the protein structure of the ...

Once at the lysosome, ALG2, which is attached to the ER exit site on one side, binds its other side to another protein, ALIX. ALIX interacts with ESCRT, a protein complex on the lysosome surface ...

Research had already established one way that cells repair leaky lysosomes. Previously, a collection of proteins known as the ESCRT machinery was found to patch up holes in the organelles’ membranes.

Further experiments showed that blocking this gene’s activity activated lysosomes—cellular compartments responsible for breaking down waste. As a result, toxic tau proteins were encapsulated and ...

KANAZAWA, Japan, April 2, 2025 /PRNewswire/ -- Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in Nature Communications how the targeted suppression of lysosome ...

Four University of Iowa faculty members have been named 2024 fellows of the American Association for the Advancement of ...

On screening human cells to identify proteins that shuttled from the cytosol to the nucleus during STING activation, they identified 17 candidates. Among these, the transcription factors EB (TFEB) and ...

Yolk proteins are the most abundant proteins in ... the intestine and transported into the germline via RME-2, impairing lysosomal activity in these tissues，which leads to the deterioration ...