He labeled proteins and followed them in their journey through the cell. He observed that the lysosomes described by de Duve contained fragments of the labeled proteins, and concluded that ...

The hormones insulin and erythropoietin (EPO) are both examples of vesicular proteins. The ER, Golgi apparatus, and lysosomes are all members of a network of membranes, but they are not continuous ...

The team also ran experiments to confirm that the protein is essential for moving fats out of lysosomes and that certain parts of Spns1 are crucial for its function. The study revealed the ...

Research had already established one way that cells repair leaky lysosomes. Previously, a collection of proteins known as the ESCRT machinery was found to patch up holes in the organelles’ membranes.

Once at the lysosome, ALG2, which is attached to the ER exit site on one side, binds its other side to another protein, ALIX. ALIX interacts with ESCRT, a protein complex on the lysosome surface ...

The biotech is focusing on precision, small-molecule medicines that work via a process known as cellular clearance by activating the lysosome, sometimes referred to as the cell’s recycling and ...

Further experiments showed that blocking this gene’s activity activated lysosomes—cellular compartments responsible for breaking down waste. As a result, toxic tau proteins were encapsulated and ...

Kanazawa University, report in Nature Communications how the targeted suppression of lysosome function may lead to brain cancer therapy.

Yolk proteins are the most abundant proteins in ... the intestine and transported into the germline via RME-2, impairing lysosomal activity in these tissues，which leads to the deterioration ...