The fatty membrane surrounding every living cell is a vibrant environment where countless biological processes take place.

Yamuna Krishnan at the University of Chicago have identified the protein responsible for a key role in how lysosomes work: how calcium ions get into lysosomes. Published in Science Advances ...

Lysosomes are organelles found within nearly all eukaryotic cells and are responsible for breaking down larger molecules such as proteins, fats and carbs. Lysosomal exocytosis occurs when the ...

Lysosomes are organelles found within nearly all eukaryotic cells and are responsible for breaking down larger molecules such as proteins, fats and carbs. Lysosomal exocytosis occurs when the ...

Research had already established one way that cells repair leaky lysosomes. Previously, a collection of proteins known as the ESCRT machinery was found to patch up holes in the organelles’ membranes.

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

On screening human cells to identify proteins that shuttled from the cytosol to the nucleus during STING activation, they identified 17 candidates. Among these, the transcription factors EB (TFEB) and ...

Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...

The autophagosomes, autolysosomes and lysosomes can be considered as different ... and metabolic disorders like diabetes and cancer. Various proteins and small molecules work in tandem to regulate ...