Figure 1: Main functions of the lysosome and their relationship with key cellular processes. Lysosomes are involved in the degradation and recycling of intracellular material (via autophagy) and ...

Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium ...

“If something happens and a molecule grows in abundance 200-fold in the lysosome, you would see only a two-fold increase if you look at the whole cell.” By isolating lysosomes from the rest of the ...

Find out how vesicles function in the body and what the five main types of vesicle are. We also discuss how vesicles interact with other cells and pathogens.

This dual-function secretory–lysosomal organelle — termed a secretory lysosome — is unusual in that, in addition to the main function of conventional lysosomes (that is, the degradation of ...

Scientists uncover novel function of autophagy protein ATG-9 in regulating lysosome integrity. Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste ...

More information: Hongwen Chen et al, Molecular basis of Spns1-mediated lysophospholipid transport from the lysosome, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas ...

The big challenge now is to show that granulins function in lysosomes, and what they do there, he said. Paired for Processing. Progranulin (green) and cathepsin L (red) meet up in Lamp2-positive ...

“What’s beautiful about this system is that all of the components of the PITT pathway were known to exist, but they weren’t known to interact in the sequence or for the function of lysosome repair,” ...

The team discovered that peroxidation of lysosomes plays a key role in the execution of ferroptosis-mediated cell death. Additionally, they found that lysosomal lipid peroxidation causes the membrane ...

In diseases due to exposure to toxic particles like gout, macrophages elicit separate pathways for inflammation and lysosomal ...