“If something happens and a molecule grows in abundance 200-fold in the lysosome, you would see only a two-fold increase if you look at the whole cell.” By isolating lysosomes from the rest of the ...

Researchers published their results in the Journal of Cell Biology on January 3, 2025.. Even more fascinating is the intricate relationship between lysosomal exocytosis and focal adhesions ...

Lysosomes digest excess or worn-out organelles, food particles, and engulf viruses or bacteria. The membrane around a lysosome allows the digestive enzymes to work at the 4.5 pH they require.

More information: Yuma Saimoto et al, Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization, Nature Communications (2025). DOI: 10.1038/s41467 ...

Moreover, administration of chloroquine-a drug that promotes lysosomal membrane damage-facilitates ferroptosis in cancer cells that are less sensitive to this process. Read the full story here .

"Interestingly, in cancer cells that are less susceptible to ferroptosis, lipid peroxidation occurred in the lysosomes, but this did not lead to lysosomal membrane damage," continues Yamada.

Detecting problems with lysosomes is the focus of a new set of fluorescent probes. "A lot of diseases are related to problems with lysosome functions," says a chemistry doctoral candidate involved ...

The lysosome was once thought of as the trash can of the cell, a dead-end destination where cellular debris was sent for disposal. But a growing body of research shows that this enzyme-filled ...

A team of researchers led by Osaka University unravel a tangle of pathways involving calcium, lipids, and the degradation of damaged lysosomes that is essential for preventing crystal-induced ...