They described the membrane-like barrier as a "saclike structure surrounded by ... them in their journey through the cell. He observed that the lysosomes described by de Duve contained fragments ...

Fats and other cellular materials reach the lysosome through three main pathways: endocytosis, phagocytosis, and autophagy. In endocytosis, the cell takes in materials from outside by wrapping ...

Research had already established one way that cells repair leaky lysosomes. Previously, a collection of proteins known as the ESCRT machinery was found to patch up holes in the organelles’ membranes.