Taken together, we showed that knockout of PDK1 indirectly alters the PI3K/PDK1 signaling axis by regulating gene transcription of Lyn, PI3K subunits and phosphoinositide-modifying enzymes.

Rabbit polyclonal antibodies against AKT, pAKT (Ser473), caspase 3 and 9, Cbl, JAK2, pJAK2(Tyr1007/1008), Lyn, pLyn(Tyr396), Hck, and PARP, PI3K p85 STAT5, pSTAT5(Tyr694), were obtained from Cell ...

Researchers unveil PI3K enzyme's dual accelerator and brake mechanisms Date: April 24, 2024 Source: Tohoku University Summary: The enzyme PI3K plays a critical role in cell migration. Scientists ...

The discovery of phosphatidylinositol 3-kinase (PI3K) changed the way we view and understand growth-factor signaling. From early on, it became clear that PI3K plays an important role in many ...

The search for alternative treatments led to the finding that the phosphatidylinositol-3-kinase (PI3K) pathway that controls cell metabolism, growth, division, and survival and allows the cells to ...

Under the amended agreement, Infinity continues to retain full worldwide rights to IPI-145, a potent, oral inhibitor of PI3K-delta and PI3K-gamma, as well as worldwide rights to any future product ...

In a preclinical study evaluating an HSP90 binding miniature drug conjugate with a pan-PI3K payload in solid tumors, the licensed product portfolio demonstrated rapid and sustained tumor ...

And that followed a similar decision by Secura Bio regarding its FL indication for PI3K drug Copiktra (duvelisib) – which is also approved for chronic lymphocytic leukaemia (CLL) – last December.

The FDA recently put the spotlight on the concerning side effects of marketed PI3K inhibitors for blood cancers. Similarly, investigators in the U.K. recorded a high level of side effects among ...